Ritonavir: May increase the serum concentration of TraZODone. Management: Consider using a lower dose of trazodone when used in combination with ritonavir. Use only the dropper that comes with the bottle to carefully measure out each dose. PVCs, VT; use with caution in patients with preexisting cardiovascular disease. Has been used for the management of anxiety states. Workman EA, Tellian F, Short D; Tellian; Short May 1992. "Trazodone induction of migraine headache through mCPP". The American Journal of Psychiatry. 149 5: 712. cheap minocycline walmart minocycline
Although there has been no systematic evaluation of the efficacy of Desyrel beyond six weeks, it is generally recommended that a course of antidepressant drug treatment should be continued for several months. Prescribe in smallest quantity consistent with good patient management to reduce risk of overdosage. Your healthcare provider will want to see you often while you are taking trazodone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor. Sufficient data in humans is also lacking. Additionally, trazodone may be found in the maternal milk in significant concentrations. The use in breastfeeding women should be carefully weighed against possible risks.
Rickels K, Downing R, Schweizer E, Hassman H; Downing; Schweizer; Hassman November 1993. "Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam". Arch. Gen. Psychiatry. Although trazodone may improve sleep at first, the effect may not continue past several weeks. Taking trazodone may also worsen sleepiness during the daytime, and morning grogginess. Plus, the side effect of sedation may not actually improve depression or insomnia. Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure black-out or convulsions or breathing that slows or stops. What should I avoid while taking Desyrel trazodone?
Irregular or fast heartbeat or faint QT prolongation. Le Bon O; Murphy JR; Staner L; Hoffmann G; Kormoss N; Kentos M; Dupont P; Lion K; Pelc I; Verbanck P August 2003. "Double-blind, placebo-controlled study of the efficacy of trazodone in alcohol post-withdrawal syndrome: polysomnographic and clinical evaluations". J Clin Psychopharmacol. The dosage should be initiated at a low level and increased gradually, noting the clinical response and any evidence of intolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage. Desyrel should be taken shortly after a meal or light snack. Symptomatic relief may be seen during the first week, with optimal antidepressant effects typically evident within two weeks. Twenty-five percent of those who respond to Desyrel require more than two weeks up to four weeks of drug administration.
Risk of suicidality; importance of patients, caregivers, and families being alert to and immediately reporting emergence of suicidality, worsening depression, or unusual changes in behavior, especially during the first few months of therapy or during periods of dosage adjustment. 212 213 218 See Worsening of Depression and Suicidality Risk under Cautions. In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitors. Ritonavir, a potent CYP3A4 inhibitor, increased the C max, AUC, and elimination half-life, and decreased clearance of trazodone after administration of ritonavir twice daily for 2 days. Adverse effects including nausea, hypotension, and syncope were observed when ritonavir and trazodone were co-administered. It is likely that ketoconazole, indinavir, and other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrations, with the potential for adverse effects. If trazodone is used with a potent CYP3A4 inhibitor, a lower dose of trazodone should be considered. There has been a long-standing concern that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients. Antidepressants increased the risk of suicidal thinking and behavior suicidality in short-term studies in children and adolescents with Major Depressive Disorder MDD and other psychiatric disorders. Logan BK, Costantino AG, Rieders EF, Sanders D; Costantino; Rieders; Sanders Nov 2010. Marek GJ, McDougle CJ, Price LH, Seiden LS; McDougle; Price; Seiden 1992. "A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action". Psychopharmacology. ADH syndrome, tardive dyskinesia, unexplained death, urinary incontinence, urinary retention, urticaria, vasodilation, vertigo and weakness. Desyrel is indicated for the treatment of depression. The efficacy of Desyrel has been demonstrated in both inpatient and outpatient settings and for depressed patients with and without prominent anxiety. CYP3A4 Inducers Strong: May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Pregnant women exposed to antidepressants during pregnancy are encouraged to enroll in the National Pregnancy Registry for Antidepressants NPRAD. Women 18 to 45 years of age or their health care providers may contact the registry by calling 844-405-6185. Enrollment should be done as early in pregnancy as possible. Store at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. Do not store in the bathroom. Do not freeze the liquid. Keep all medicines away from children and pets. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Conivaptan: May increase the serum concentration of CYP3A4 Substrates. Bleeding risk: Drugs that interfere with serotonin reuptake eg, SSRIs have been associated with bleeding ranging from relatively minor bruising and epistaxis to life-threatening hemorrhage; similar to these agents, trazodone may also impair platelet aggregation resulting in increased risk of bleeding events, particularly if used concomitantly with aspirin, NSAIDs, warfarin or other anticoagulants. Take this medication exactly as prescribed. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. Trazodone's propensity to cause sedation is a dual-edged sword. For many patients, the relief from agitation, anxiety, and insomnia can be rapid; for other patients, including those individuals with considerable and feelings of low energy, therapeutic doses of trazodone may not be tolerable because of sedation. Trazodone elicits in some patients, probably as a consequence of α 1-adrenergic receptor blockade. Mania has been observed in association with trazodone treatment, including in patients with bipolar disorder, as well as in patients with previous diagnoses of major depression. Retrieved 20 April 2017.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: current dehydration or mineral imbalance, a certain type of bowel disease acute ulcerative colitis personal or family history of glaucoma angle-closure type. Trazodone is not approved for use in pediatric patients. a See Pediatric Use under Cautions. Clostridium difficile-associated diarrhea following recent antibiotic therapy, bacterial infection of the gut caused by E. coli, Salmonella, Shigella. Trazodone may cause a condition that affects the rhythm QT prolongation. Antipsychotic Agents. Specifically, serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotic Agents may enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. Keep all regular medical and laboratory appointments. Initially, 150 mg daily, given in divided doses. AHFS drug information 2001. McEvoy GK, ed. Trazodone hydrochloride. baclofen
Silvestrini B 1989. "Trazodone: from the mental pain to the "dys-stress" hypothesis of depression". Clin Neuropharmacol. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Nierenberg AA, Adler LA, Peselow E, Zornberg G, Rosenthal M July 1994. Goldstein I, Krane RJ, Diagnosis and therapy of erectile dysfunction. In: Wash PC, Retik AB, Stamey TA, Vaughan ED, eds. Who should not take Oleptro? Be open to new ideas. Your therapist may have suggestions that sound strange. He or she may push you to do things that feel awkward or uncomfortable. But try to stay open. Give new approaches a try. You may find them more helpful than you expected. Also tell your doctor if you have or have ever had high blood pressure, sickle cell anemia a disease of the red blood cells multiple myeloma cancer of the plasma cells leukemia cancer of the white blood cells cavernosal fibrosis, Peyronie's disease a condition that affects the shape of the penis such as angulation or heart, liver or kidney disease. American Psychiatric Association. Practice guideline for the treatment of patients with bipolar disorder revision. Am J Psychiatr. This medication should not be used if you have certain medical conditions.
Taking certain MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Highest Risk QTc-Prolonging Agents: QTc-Prolonging Agents Indeterminate Risk and Risk Modifying may enhance the QTc-prolonging effect of Highest Risk QTc-Prolonging Agents. Management: Avoid such combinations when possible. Use should be accompanied by close monitoring for evidence of QT prolongation or other alterations of cardiac rhythm. This list is not complete and many other drugs can interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. What should I avoid while taking Oleptro? Treatment should be started with low initial doses of 25 to 50 mg daily in divided doses or in an evening single dose. The dose may be increased slowly to a maximum of 300 mg daily in ambulatory patients and to 600 mg daily in hospitalized patients. Geriatric and emaciated patients should begin with 100 mg daily; this dose may be slowly increased to 300 mg. The duration of treatment should be at least one month. A 50 mg dose is recommended when using Trazodone as a sleep aid. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Sufficient data in humans is lacking. The use should be justified by the severity of the condition to be treated. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Please refer to the for information on shortages of one or more of these preparations. What should I discuss with my healthcare provider before taking Desyrel trazodone? Talk to your doctor about the risk of taking trazodone. Aranow RB, Hudson JI, Pope HG Jr et al. Elevated antidepressant plasma levels after addition of fluoxetine. Am J Psychiatry. Oleptro that is written for health professionals. You may have your pulse and taken lying down and then again after quickly standing, in order to see what changes are provoked by these different positions. Schatzberg, AF; Nemeroff, CB, eds. 2009. Swerdlow NR, Andia AM. Trazodone-fluoxetine combination for treatment of obsessive-compulsive disorder. Am J Psychiatry. anyone buy plavix online
Tatsumi M, Groshan K, Blakely RD, Richelson E; Groshan; Blakely; Richelson December 1997. This drug should not be used with the following medications because very serious interactions may occur: ambenonium, pramlintide. Because of the absence of experience, concurrent administration of should be avoided. Trazodone may cause hypotension including orthostatic hypotension and syncope; caution is required if it is given to patients receiving antihypertensive drugs and an adjustment in the dose of the antihypertensive medication may be required. Allow 14 days to elapse between discontinuing an MAO inhibitor intended to treat psychiatric disorders and initiation of trazodone. This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to narcotic pain relievers, but it acts mainly to slow the gut. Atropine belongs to a class of drugs known as anticholinergics, which help to dry up body fluids and also slow gut movement. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically more depressed, or have thoughts about suicide or hurting yourself. In these studies, patients took either a placebo sugar pill or an antidepressant for 1 to 4 months. No one committed suicide in these studies, but some patients became suicidal. On sugar pills, 2 out of every 100 became suicidal. On the antidepressants, 4 out of every 100 patients became suicidal. American Academy of Child and Adolescent Psychiatry AACAP. AACAP responds to the new FDA warnings on pediatric antidepressant medications. Extended release: Refer to adult dosing. Use with caution in the elderly; clinical experience is limited. Very serious possibly life-threatening effects may occur if too much of this medication is taken by children.
Palbociclib: May increase the serum concentration of CYP3A4 Substrates. If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Discontinue immediately if prolonged or inappropriate erections occur. Regular exercise promotes healthy sleep. Don't work on a computer at all for at least an hour before going to bed. Individualize dosages according to individual requirements and response. Tedizolid: May enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. Connor KP, Lynch JH. Priapism: current concepts. Ann Emerg Med. 1989: 980-983. European Journal of Pharmacology. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Caution should be exercised when Oleptro is administered to a nursing woman. Your doctor may attempt to reproduce the symptoms by simulating the situation during which you usually have a fainting episode. Importance of informing patients of other important precautionary information. 201 See Cautions. generic finasteride vs mebendazole
Mitotane: May decrease the serum concentration of CYP3A4 Substrates. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take trazodone, but in some cases, a doctor may decide that trazodone is the best medication to treat a child's condition. Carefully consider these findings when assessing potential benefits and risks of trazodone in a child or adolescent for any clinical use. 212 218 223 a See Suicidality in the Boxed Warning and also see Worsening of Depression and Suicidality Risk under Cautions. Fink HA, MacDonald R, Rutks IR et al. Trazodone for erectile dysfunction: a systematic review and meta-analysis. Br J Urol. Whenever an antidepressant is started or its dose is changed, pay close attention to your child. Carbamazepine reduced plasma concentrations of trazodone when co-administered. Patients should be closely monitored to see if there is a need for an increased dose of trazodone when taking both drugs. It may take 2 weeks or longer before you notice the full effects of this medication. Tell your doctor if your condition persists or worsens. Administer orally after a meal or a light snack. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. The trazodone immediate-release tablet should be taken after a meal or a snack. Do not stop taking any medications without consulting your healthcare provider. Survey on the Usefulness of Trazodone in Patients with PTSD with Insomnia or Nightmares". Pharmacopsychiatry. If you take a MAOI. Do not share this medication with others. It is against the law. Vetulani J, Sansone M, Baran L, Hano J; Sansone; Baran; Hano 1984. "Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice". Psychopharmacology. Desyrel trazodone hydrochloride is not recommended for use during the initial recovery phase of myocardial infarction.
What is the most important information I should know if my child is being prescribed an antidepressant? CYP3A4 Inhibitors Strong: May decrease the metabolism of CYP3A4 Substrates. Older adults may be more sensitive to the side effects of this drug, especially QT prolongation see above. The most severe reactions reported to have occurred with overdose of Desyrel alone have been priapism, respiratory arrest, seizures, and EKG changes. The reactions reported most frequently have been drowsiness and vomiting. Discontinuation of therapy: Refer to adult dosing. II ecstasy immunoassay in urine". J Anal Toxicol. Available as trazodone hydrochloride; dosage is expressed in terms of the salt. The ACOG recommends that therapy with antidepressants during pregnancy be individualized; treatment of depression during pregnancy should incorporate the clinical expertise of the mental health clinician, obstetrician, primary health care provider, and pediatrician. According to the American Psychiatric Association APA the risks of medication treatment should be weighed against other treatment options and untreated depression. Consideration should be given to using agents with safety data in pregnancy. For women who discontinue antidepressant medications during pregnancy and who may be at high risk for postpartum depression, the medications can be restarted following delivery. Treatment algorithms have been developed by the ACOG and the APA for the management of depression in women prior to conception and during pregnancy ACOG 2008; APA 2010; Yonkers 2009. Take your medicine as prescribed. Get into good habits. Take your medicine at the same time every day. Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking trazodone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Get a weekly pillbox, which will make it easy to see if you've missed a dose. If you are using a liquid form, carefully measure your prescribed dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose. The possibility of in depressed patients remains during treatment and until significant remission occurs. The number of tablets prescribed at any one time should take into account this possibility, and patients with should never have access to large quantities of trazodone. Induction of is not recommended. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. pripsen
Bristol-Myers Squibb Company. Desyrel trazodone tablets prescribing information. American Psychiatric Association APA. How should I take Oleptro? Angelini Pharma Inc. Gaithersburg, MD 20877. May worsen psychosis in some patients or precipitate a shift to mania or hypomania in patients with bipolar disorder. Monotherapy in patients with bipolar disorder should be avoided. Patients presenting with depressive symptoms should be screened for bipolar disorder. Trazodone is not FDA approved for the treatment of bipolar depression. All pediatric patients being treated with antidepressants for any indication should be observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Such observation would generally include at least weekly face-to-face contact with patients or their family members or caregivers during the first 4 weeks of treatment, then every other week visits for the next 4 weeks, then at 12 weeks, and as clinically indicated beyond 12 weeks. Additional contact by telephone may be appropriate between face-to-face visits. Likewise, the best practice is to wake up around the same time every day with not more than an hour's difference on the weekends. Early recognition of any abnormal erectile function is important, including prolonged or inappropriate erections, and should prompt discontinuation of trazodone treatment.
Desyrel may enhance the response to alcohol, barbiturates, and other CNS depressants. Alcohol can make the side effects from trazodone worse. Prescriptions should be written for the smallest quantity consistent with good patient care. The patient's family or caregiver should be alerted to monitor patients for the emergence of suicidality and associated behaviors such as anxiety, agitation, panic attacks, insomnia, irritability, hostility, impulsivity, akathisia, hypomania, and mania; patients should be instructed to notify their healthcare provider if any of these symptoms or worsening depression or psychosis occur. Many prescription and nonprescription medicines can delay or disrupt sleep. If you take any on a regular basis, check with your doctor about this. For the average person who has occasional brief bouts of insomnia, making to your lifestyle may help, including: avoiding big meals, alcohol, smoking and exercising late at night or working or watching TV in bed. See sidebar for a full list. To try to prevent suicidal thought and actions in your child, pay close attention to changes in her or his moods or actions, especially if the changes occur suddenly. Occasional sinus bradycardia has occurred in long-term studies. Antagonist. This may cause serotonin syndrome. Management: Consider alternatives, and use conservative initial dosing. And, trazodone has certain risks of its own. In particular, it's more likely than the newer sleep drugs, particularly the short-acting ones, to leave you feeling drowsy the next day, which increases the chance of accidents. It can also cause abnormally low blood pressure and, in turn, dizziness or even fainting, particularly in seniors. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms. Usually, the most important consideration is managing the depression, which should be treated separately with a more effective antidepressant medication, counseling, or both. Serotonin Modulators. Specifically, the risk of serotonin syndrome or serotonin toxicity may be increased. Antagonist. While methylene blue and linezolid are expected to interact, specific recommendations for their use differ from other monoamine oxidase inhibitors. Refer to monographs specific to those agents for details. Exceptions: Linezolid; Methylene Blue; Tedizolid. Know all of the medicines that you take. stendra purchase usa
While trazodone is not a true member of the class of antidepressants, it does still share many properties of the SSRIs, especially the possibility of if the medication is stopped too quickly. Care must, therefore, be taken when coming off the medication, usually by a gradual process of tapering down the dose over a period of time. Haria M, Fitton A, McTavish D April 1994. "Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders". Drugs Aging. Note: Clinical practice guidelines recommend doses up to 600 mg daily without noted consideration to inpatient or outpatient status APA 2010; Bauer 2013. What are the possible side effects of Oleptro? Extended release tablet: Take on an empty stomach; swallow whole or as a half tablet without food. Tablet may be broken along the score line, but do not crush or chew. Discontinuation of therapy: Upon discontinuation of antidepressant therapy, gradually taper the dose to minimize the incidence of withdrawal symptoms and allow for the detection of re-emerging symptoms. Evidence supporting ideal taper rates is limited. APA and NICE guidelines suggest tapering therapy over at least several weeks with consideration to the half-life of the antidepressant; antidepressants with a shorter half-life may need to be tapered more conservatively. In addition for long-term treated patients, WFSBP guidelines recommend tapering over 4 to 6 months. What other drugs will affect Desyrel trazodone? Journal of Psychopharmacology Oxford, England.
MAO inhibitor recommendations: Refer to adult dosing. Concomitant administration of antihypertensive therapy may require a reduction in dosage of the antihypertensive agents. Antidepressants are used to treat depression and other illnesses. Depression and other illnesses can lead to suicide. In some children and teenagers, treatment with an antidepressant increases suicidal thinking or actions. It is important to discuss all the risks of treating depression and also the risks of not treating it. You and your child should discuss all treatment choices with your healthcare provider, not just the use of antidepressants. Episodes of have been reported in a small number of patients. The majority of these patients were already receiving therapy for a previously diagnosed seizure disorder. Bardin ED, Krieger JN. Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. Int Urol Nephrol. Monitor cardiac rhythm and vital signs. Extended release tablet: Store at room temperature of 15ºC to 30ºC 59ºF to 86ºF. Protect from light. blat.info lotriderm
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Inhibitors or inducers of CYP3A4: Potential pharmacokinetic interaction altered plasma trazodone concentrations. For some children and teenagers, the risk of suicidal actions may be especially high. Major Depressive Episode implies a prominent and relatively persistent nearly every day for at least two weeks depressed or dysphoric mood that usually interferes with daily functioning, and includes at least four of the following eight symptoms: change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigability, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and suicidal ideation or attempts.
Maximum 600 mg daily. Drowsiness, dry mouth, dizziness or lightheadedness, headache, blurred vision, nausea or vomiting. Borras L; de Timary P; Constant EL; Huguelet P; Eytan A November 2006. "Successful treatment of alcohol withdrawal with trazodone". Pharmacopsychiatry. 39 6: 232.
Allow 14 days to elapse between discontinuing trazodone and initiation of an MAO inhibitor intended to treat psychiatric disorders. Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down. Families and caregivers of patients should be advised to observe for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt. Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms. Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication.
Dextromethorphan is a cough suppressant that affects a certain part of the brain cough center reducing the urge to cough. Decongestants help to relieve stuffy nose symptoms. This product also contains acetaminophen, a non-aspirin pain reliever and fever reducer. Inform your doctor if your condition does not improve after 2 days. CYP3A4 Inducers Moderate: May decrease the serum concentration of CYP3A4 Substrates. Warfarin: TraZODone may diminish the anticoagulant effect of Warfarin.